细胞因子白细胞介素27(interleukin-27, IL-27)是帮助调节免疫系统的白介素家族中的一员，在身体内具有抗炎作用，但其功能障碍与自身免疫性疾病如多发性硬化和克罗恩病密切相关。
最近， IL-27的促炎活性和其在慢性炎症性疾病中的作用越来越明显，一篇综述研究论文探讨了在一系列疾病中所呈现出的IL-27促炎活性，研究论文发表在杂志JouRNAl of Interferon & Cytokine Research (JICR)上。
研究人员Christopher Wynick, Carlene Petes和Katrina Gee解释：IL-27如何控制抗炎反应和促炎反应，取决于身体免疫反应的主要类型，疾病类型和严重程度。
研究者主要集中于白介素-27的促炎活性，认为IL-27是决定炎症反应性质的一种新兴决定因素。
原文标题：Interleukin-27 Mediates Inflammation During Chronic Disease
原文摘要：The interleukin (IL)-12 family cytokine, IL-27 has been implicated in the pathogenesis of many autoimmune inflammatory disorders, including rheumatoid arthritis, psoriasis, multiple sclerosis, Crohn's disease, and ulcerative colitis. Discovered in 2002, IL-27 has been primarily described as an anti-inflammatory cytokine with regulatory roles in multiple sclerosis and experimental autoimmune encephalitis. However, recent studies have demonstrated a pro-inflammatory function of IL-27 in both the adaptive and innate immune responses. This review will focus on the proinflammatory nature of IL-27 in chronic inflammatory skin disease and inflammatory bowel disease.
原文地址：http://online.liebertpub.com/doi/abs/10.1089/jir.2013.0154
文章来源：生物帮