Product Information
    
 
    

    

        

            

                

                
Product Name
                
                

                
Cat#
                
                

                
Size
                
                

                
Price（¥）
                
            
            

                

                
Recombinant Human soluble CD40 Ligand/TNFSF5
                
(Human sCD40 Ligand/TNFSF5)
                
                

                
90606ES10
                
                

                
10 μg
                
                

                
815.00
                
            
            

                

                
90606ES60
                
                

                
100 μg
                
                

                
3985.00
                
            
            

                

                
90606ES76
                
                

                
500 μg
                
                

                
10215.00
                
            
        
    
    
    
 
    
Product Description
    
 
    
CD40 Ligand, also known as TNFSF, a type II membrane protein with homology to TNF, is transiently expressed on activated T cells and known to be important for B cell Ig production and for activation and differentiation of monocytes and dendritic cells. Mature human CD40 Ligand consists of a 22 amino acid (aa) cytoplasmic domain, a transmembrane segment, and an 215 aa extracellular region . It is primarily expressed on activated CD4+ T lymphocytes, and also found in other types of cells, like NK cells, mast cells, basophils and eosinophils. In total CD40 ligand has three binding partners: CD40, α5β1 integrin and αIIbβ3. CD40 Ligand dysregulation on T cells and antigen presenting cells contributes to the immune deficiency associated with HIV infection and AIDS.  CD40 ligation by CD40 Ligand promotes B cell activation and T cell-dependent humoral responses.
    
 
    
Product Properties
    
 
    

    

        

            

                

                
Synonyms
                
                

                
CD154 antigen, CD154, CD40 antigen ligand, CD40 Ligand, gp39, HIGM1, T-B cell-activating molecule, T-BAM, TNFSF5, TNFSF5IMD3, TRAP
                
            
            

                

                
Accession
                
                

                
P29965
                
            
            

                

                
GeneID
                
                

                
959
                
            
            

                

                
Source
                
                

                
E.coli-derived human sCD40L protein, Met113-Leu261.
                
            
            

                

                
Molecular Weight
                
                

                
Approximately 16.3 kDa.
                
            
            

                

                
AA Sequence
                
                

                
MQKGDQNPQI AAHVISEASS KTTSVLQWAE KGYYTMSNNL VTLENGKQLT VKRQGLYYIY AQVTFCSNRE ASSQAPFIAS LWLKSPGRFE RILLRAANTH SSAKPCGQQS IHLGGVFELQ PGASVFVNVT DPSQVSHGTG FTSFGLLKL
                
            
            

                

                
Tag
                
                

                
None
                
            
            

                
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