FITC标记的中胚层诱导早期反应蛋白3抗体
产品名称： FITC标记的中胚层诱导早期反应蛋白3抗体
英文名称： Anti-MIER3/FITC
产品编号： HZ-18939R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-MIER3/FITC Conjugated antibody
FITC标记的中胚层诱导早期反应蛋白3抗体
| 英文名称 | Anti-MIER3/FITC |
| 中文名称 | FITC标记的中胚层诱导早期反应蛋白3抗体 |
| 别 名 | DKFZp686L09111; DKFZp781G1119; DKFZP781I1119; FLJ35954; Mesoderm induction early response 1 family member 3; Mesoderm induction early response protein 3; Mi-er3; MIER 3; MIER3; MIER3_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 生长因子和激素 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Ferret, Baboon, Rhesus monkey, Gorilla, Orangutan |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 61kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MIER3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The mesoderm induction early response (MIER) protein family (also known as the fibroblast growth factor (FGF)-regulated immediate-early protein family) comprises a group of proteins that are activated by FGF (fibroblast growth factor). This suggests that MEIR proteins may play a significant role in FGF-regulated cellular activities and in the progression of certain cancers. MIER proteins contain one SANT domain, which is involved in transcriptional activation and repression, and one ELM2 domain, which was first characterized in egl-27, a gene that is critically involved in embryonic patterning of C. elegans. MIER1, formerly known as early response 1 (ER1), was first cloned and characterized in Xenopus. Expression of MIER1 is negligible in most normal tissues, but has been found to be upregulated in breast carcinoma cell lines and tumors. MIER1 functions as a transcriptional repressor of a number of genes including Sp1 target genes, most likely through interaction with HDAC1. Function: Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing. Subunit: Interacts with HDAC1. Part of a complex containing at least CDYL, MIER1, MIER2, HDAC1 and HDAC2. Subcellular Location: Nucleus; Cytoplasm Tissue Specificity: Ubiquitously expressed, but at very low levels. However, consistent level of expression are observed in heart, testis, thyroid, ovary and adrenal gland. Transcripts are up-regulated in breast carcinoma cell lines and tumor. Similarity: Contains 1 ELM2 domain. Contains 1 SANT domain. Database links: Entrez Gene: 166968 Human SwissProt: Q7Z3K6 Human SwissProt: Q7Z3K6-1 Human SwissProt: Q7Z3K6-2 Human SwissProt: Q7Z3K6-3 Human SwissProt: Q7Z3K6-4 Human SwissProt: Q7Z3K6-5 Human Unigene: 657594 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
中胚层诱导早期反应（MIER）蛋白家族（也称为成纤维细胞生长因子（FGF）调节的即刻早期蛋白家族）包括一组被成纤维细胞生长因子（FGF）激活的蛋白质。这表明MEIR蛋白可能在FGF调节的细胞活性和某些癌症的进展中起重要作用。MIER蛋白包含一个参与转录激活和抑制的SANT结构域和一个ELM2结构域，该结构域首先以egl-27为特征，egl-27基因与秀丽线虫的胚胎模式密切相关。MIER1，以前被称为早期反应1（Er1），首先在Xenopus克隆和鉴定。MIER1在大多数正常组织中表达可忽略不计，但在乳腺癌细胞系和肿瘤中表达上调。MIER1是许多基因的转录抑制因子，包括Sp1靶基因，很可能通过与HDAC1的相互作用发挥作用。