The tripartite motif (TRIM) family of proteins are characterized by a conserved TRIM domain that includes a coiled-coil region, a B-box type zinc finger, one RING finger and three zinc-binding domains. TRIM2 (tripartite motif-containing 2), also known as RNF86, is a 744 amino acid protein that localizes to cytoplasmic filaments and contains a variety of domains that are characteristic to TRIM proteins, including a RING-type zinc finger and a B box-type zinc finger, as well as one filamin repeat and six NHL repeats. Via its NHL repeats, TRIM2 interacts with Myosin V and is thought to contribute to the alternation of neural cellular mechanisms, possibly protecting cells from neurodegeneration. The gene encoding TRIM2 maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes.