HK2 (Center) Peptide
产品名称： HK2 (Center) Peptide
英文名称： HK2 (Center) Peptide
产品编号： P3159
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- 邮编 : 11493
- 所在区域 : 台湾
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- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of HK2.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to internal region of human HK2.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Biologic correlation between glucose transporters, hexokinase-II, Ki-67 and FDG uptake in malignant melanoma.
Park SG, Lee JH, Lee WA, Han KM.Nucl Med Biol. 2012 Aug 14.
- 2.
- Human hexokinase II gene: exon-intron organization, mutation screening in NIDDM, and its relationship to muscle hexokinase activity.
Lehto M, Huang X, Davis EM, Le Beau MM, Laurila E, Eriksson KF, Bell GI, Groop L.Diabetologia. 1995 Dec;38(12):1466-74.
- 3.
- Amino acid substitutions in hexokinase II among patients with NIDDM.
Laakso M, Malkki M, Deeb SS.Diabetes. 1995 Mar;44(3):330-4.
- 4.
- Analysis of the hexokinase II gene in subjects with insulin resistance and NIDDM and detection of a Gln142-->His substitution.
Vidal-Puig A, Printz RL, Stratton IM, Granner DK, Moller DE.Diabetes. 1995 Mar;44(3):340-6.
- Applications
- Western Blot (Cell lysate)
- The HK2 polyclonal antibody (Cat # PAB4005) is used in Western blot to detect HK2 in A-375 cell lysate.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with HK2 polyclonal antibody (Cat # PAB4005) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
- Entrez GeneID:
- 3099
- Protein Accession#:
- P52789
- Gene Name:
- HK2
- Gene Alias:
- DKFZp686M1669,HKII,HXK2
- Gene Description:
- hexokinase 2
- Omim ID:
- 601125
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells. [provided by RefSeq
- Other Designations:
- hexokinase-2, muscle
- Gene Pathway
- Amino sugar and nucleotide sugar metabolism
- Biosynthesis of alkaloids derived from histidine and purine
- Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of alkaloids derived from terpenoid and polyketide
- Biosynthesis of phenylpropanoids
- Biosynthesis of plant hormones
- Biosynthesis of terpenoids and steroids
- Fructose and mannose metabolism
- Galactose metabolism
- Glycolysis / Gluconeogenesis
- Insulin signaling pathway
- Metabolic pathways
- Starch and sucrose metabolism
- Streptomycin biosynthesis
- Type II diabetes mellitus