GAB1 Peptide
产品名称： GAB1 Peptide
英文名称： GAB1 Peptide
产品编号： P2855
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of GAB1.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to residues surrounding Y659 of human GAB1.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein A purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Gab1 but not Grb2 mediates tumor progression in Met overexpressing colorectal cancer cells.
Seiden-Long I, Navab R, Shih W, Li M, Chow J, Zhu CQ, Radulovich N, Saucier C, Tsao MS.Carcinogenesis. 2008 Mar;29(3):647-55. Epub 2008 Jan 12.
- 2.
- Protein kinase C-betaII represses hepatocyte growth factor-induced invasion by preventing the association of adapter protein Gab1 and phosphatidylinositol 3-kinase in melanoma cells.
Oka M, Kikkawa U, Nishigori C.J Invest Dermatol. 2008 Jan;128(1):188-95. Epub 2007 Jul 12.
- 3.
- The scaffolding adapter Gab1 mediates vascular endothelial growth factor signaling and is required for endothelial cell migration and capillary formation.
Laramee M, Chabot C, Cloutier M, Stenne R, Holgado-Madruga M, Wong AJ, Royal I.J Biol Chem. 2007 Mar 16;282(11):7758-69. Epub 2006 Dec 17.
- Applications
- Western Blot (Transfected lysate)
- Western blot analysis of GAB1 (arrow) using GAB1 polyclonal antibody (Cat # PAB3514).
293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the GAB1 gene (Lane 2).
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with GAB1 polyclonal antibody (Cat # PAB3514) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated.
- Entrez GeneID:
- 2549
- Protein Accession#:
- NP_002030;Q13480
- Gene Name:
- GAB1
- Gene Alias:
- -
- Gene Description:
- GRB2-associated binding protein 1
- Omim ID:
- 604439
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- -
- Interactome
