Product Information
    
 
    

    

        

            

                

                
Product Name
                
                

                
Cat#
                
                

                
Size
                
                

                
Price（¥）
                
            
            

                

                
Recombinant Human Interleukin-11 (Human IL-11)
                
                

                
90110ES10
                
                

                
10 μg
                
                

                
1855.00
                
            
            

                

                
90110ES60
                
                

                
100 μg
                
                

                
13615.00
                
            
            

                

                
90110ES76
                
                

                
500 μg
                
                

                
35395.00
                
            
        
    
    
    
 
    
Product Description
    
 
    
Interleukin 11 (IL-11), a member of the IL-6 family of cytokines, exerts pleiotropic activities by stimulating hemopoiesis and thrombopoiesis, regulating macrophage differentiation, and conferring mucosal protection in the intestine. These effects are mediated by a multimeric complex comprising the ligand-binding IL-11R± and the ubiquitously expressed gp130R-subunit, which together, trigger intracellular signaling and engagement of Stat3. Mature human IL-11 shares 88%, 88%, and 96% aa sequence identity with mouse, rat and canine IL-11, respectively. IL-11 is a pleotropic cytokine produced by lung stromal cells in response to respiratory viruses, cytokines, and histamine. The functions of IL-11 are that it directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells, and induces megakaryocyte maturation resulting in increased platelet production.
    
 
    
Product Properties
    
 
    

    

        

            

                

                
Synonyms
                
                

                
Adipogenesis inhibitory factor, AGIF, IL-11, IL-11Oprelvekin, interleukin 11, interleukin-11, Oprelvekin
                
            
            

                

                
Accession
                
                

                
P20809
                
            
            

                

                
GeneID
                
                

                
3589
                
            
            

                

                
Source
                
                

                
E.coli-derived Human IL-11, Pro22-Leu199, with an N-terminal Met.
                
            
            

                

                
Molecular Weight
                
                

                
Approximately 19.1 kDa.
                
            
            

                

                
AA Sequence
                
                

                
MPGPPPGPPR VSPDPRAELD STVLLTRSLL ADTRQLAAQL RDKFPADGDH NLDSLPTLAM SAGALGALQL PGVLTRLRAD LLSYLRHVQW LRRAGGSSLK TLEPELGTLQ ARLDRLLRRL QLLMSRLALP QPPPDPPAPP LAPPSSAWGG IRAAHAILGG LHLTLDWAVR GLLLLKTRL
                
            
            

                

                
Tag
                
                

                
None
                
            
            

                

                
Physical Appearance
                
                

                
Sterile Filtered White lyophilized (freeze-dried) powder.
                
            
            

                

                
Purity