FITC标记的胰岛细胞自身抗原相关蛋白PTPRN2抗体
产品名称： FITC标记的胰岛细胞自身抗原相关蛋白PTPRN2抗体
英文名称： Anti-PTPRN2/FITC
产品编号： HZ-20830R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-PTPRN2/FITC Conjugated antibody
FITC标记的胰岛细胞自身抗原相关蛋白PTPRN2抗体
| 英文名称 | Anti-PTPRN2/FITC |
| 中文名称 | FITC标记的胰岛细胞自身抗原相关蛋白PTPRN2抗体 |
| 别 名 | IA 2beta; IA2beta; IAR; IAR/receptor like protein tyrosine phosphatase; ICAAR; Islet cell autoantigen related protein; Islet cell autoantigen-related protein; Phogrin; Protein tyrosine phosphatase receptor pi; Protein tyrosine phosphatase, receptor type, N polypeptide 2; PTPR2_HUMAN; Ptprn2; PTPRP; R PTP N2; R-PTP-N2; Receptor-type tyrosine-protein phosphatase N2; Tyrosine phosphatase IA 2 beta. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Mouse, Rat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 109kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 2mg/1ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse PTPRN2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008] Function: Implicated in development of nervous system and pancreatic endocrine cells. Subcellular Location: Membrane. Tissue Specificity: Highest levels in brain and pancreas. Lower levels in trachea, prostate, stomach and spinal chord. Post-translational modifications: Appears to undergo multiple proteolytic cleavage at consecutive basic residues. Similarity : Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily. Contains 1 tyrosine-protein phosphatase domain. Database links: Entrez Gene: 5799 Human Entrez Gene: 19276 Mouse Entrez Gene: 29714 Rat Omim: 601698 Human SwissProt: Q92932 Human SwissProt: P80560 Mouse SwissProt: Q63475 Rat Unigene: 490789 Human Unigene: 206054 Mouse Unigene: 11044 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
由该基因编码的蛋白质是蛋白酪氨酸磷酸酶（PTP）家族的成员。PTP是调节多种细胞过程的信号分子，包括细胞生长、分化、有丝分裂周期和致癌转化。该PTP具有胞外区、单个跨膜区和单个胞内催化区，因此代表受体型PTP。该PTP的催化结构域与PTPRN/IA-2β最为密切相关。PTP和PTPRN是胰岛素依赖性糖尿病的主要自身抗原。报道了该基因的三个选择性剪接的转录变体，它们编码不同的蛋白质。[ RefSeq，JUL 2008 ]