LIMK2 (N-term) Peptide
产品名称： LIMK2 (N-term) Peptide
英文名称： LIMK2 (N-term) Peptide
产品编号： P2828
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- 邮编 : 11493
- 所在区域 : 台湾
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of LIMK2.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human LIMK2.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Oncogenic kinase signalling.
Blume-Jensen P, Hunter T.Nature. 2001 May 17;411(6835):355-65.
- 2.
- Phosphoinositide 3-kinase signalling pathways.
Cantrell DA.J Cell Sci. 2001 Apr;114(Pt 8):1439-45.
- 3.
- The RET proto-oncogene in human cancers.
Jhiang SM.Oncogene. 2000 Nov 20;19(49):5590-7.
- Entrez GeneID:
- 3985
- Protein Accession#:
- Q99464
- Gene Name:
- LIMK2
- Gene Alias:
- -
- Gene Description:
- LIM domain kinase 2
- Omim ID:
- 601988
- Gene Ontology:
- Hyperlink
- Gene Summary:
- There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- -