Product Information
    
 
    

    

        

            

                

                
Product Name
                
                

                
Cat#
                
                

                
Size
                
                

                
Price（¥）
                
            
            

                

                
Recombinant Human Fms-related Tyrosine Kinase 3 Ligand(Human Flt-3 Ligand)
                
                

                
92259ES10
                
                

                
10 μg
                
                

                
1855.00
                
            
            

                

                
92259ES60
                
                

                
100 μg
                
                

                
10215.00
                
            
            

                

                
92259ES76
                
                

                
500 μg
                
                

                
26545.00
                
            
        
    
    
    
 
    
Product Description
    
 
    
The cytokine Fms-like tyrosine kinase 3 ligand (FLT3L), also known as Flt-3 Ligand, is an important regulator of hematopoiesis. Its receptor, Flt3, is expressed on myeloid, lymphoid and dendritic cell progenitors and is considered an important growth and differentiation factor for several hematopoietic lineages. Activating mutations of Flt3 are frequently found in acute myeloid leukemia (AML) patients and associated with a poor clinical prognosis. Mature human Flt3L consists of a 158 amino acid (aa) extracellular domain (ECD) with a cytokine-like domain and a juxtamembrane tether region, a 21 aa transmembrane segment, and a 30 aa cytoplasmic tail. At the amino acid sequence level, human and mouse FL are approximately 72% identical and the two proteins exhibit cross-species activity. The Flt3-L manifests antitumor activity, presumably due to its capacity to recruit dendritic cells and cause their proliferation.
    
 
    
Product Properties
    
 
    

    

        

            

                

                
Synonyms
                
                

                
Flt3-Ligand, FL, FLG3L, Flt3L, SL Cytokine
                
            
            

                

                
Accession
                
                

                
P49771
                
            
            

                

                
GeneID
                
                

                
2323
                
            
            

                

                
Source
                
                

                
E.coli-derived human IL-1alpha protein, Thr27-Ala181.
                
            
            

                

                
Molecular Weight
                
                

                
Approximately 17.6 kDa.
                
            
            

                

                
AA Sequence
                
                

                
TQDCSFQHSP ISSDFAVKIR ELSDYLLQDY PVTVASNLQD EELCGGLWRL VLAQRWMERL KTVAGSKMQG LLERVNTEIH FVTKCAFQPP PSCLRFVQTN ISRLLQETSE QLVALKPWIT RQNFSRCLEL QCQPDSSTLP PPWSPRPLEA TAPTA
                
            
            

                

                
Tag
                
                

                
None
                
            
            

                

                
Physical Appearance
                
                

                
Sterile Filtered White lyophilized (freeze-dried) powder.
                
            
            

                

                
Purity
                
                
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