RAD23B (C-term) Peptide
产品名称： RAD23B (C-term) Peptide
英文名称： RAD23B (C-term) Peptide
产品编号： P0996
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of RAD23B.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human RAD23B.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Structural determinants for the binding of ubiquitin-like domains to the proteasome.
Mueller TD, Feigon J.EMBO J. 2003 Sep 15;22(18):4634-45.
- 2.
- Solution structures of UBA domains reveal a conserved hydrophobic surface for protein-protein interactions.
Mueller TD, Feigon J.J Mol Biol. 2002 Jun 21;319(5):1243-55.
- 3.
- Involvement of rhp23, a Schizosaccharomyces pombe homolog of the human HHR23A and Saccharomyces cerevisiae RAD23 nucleotide excision repair genes, in cell cycle control and protein ubiquitination.
Elder RT, Song XQ, Chen M, Hopkins KM, Lieberman HB, Zhao Y.Nucleic Acids Res. 2002 Jan 15;30(2):581-91.
- Applications
- Western Blot (Cell lysate)
- The RAD23B polyclonal antibody (Cat # PAB1744) is used in Western blot to detect RAD23B in HeLa cell lysate.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with RAD23B polyclonal antibody (Cat # PAB1744) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. HC = hepatocarcinoma.
- Entrez GeneID:
- 5887
- Protein Accession#:
- P54727
- Gene Name:
- RAD23B
- Gene Alias:
- HHR23B,HR23B,P58
- Gene Description:
- RAD23 homolog B (S. cerevisiae)
- Omim ID:
- 600062
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. [provided by RefSeq
- Other Designations:
- OTTHUMP00000021857,RAD23, yeast homolog of, B,UV excision repair protein RAD23 homolog B,XP-C repair complementing complex 58 kDa,XP-C repair complementing protein
- Gene Pathway
- Related Disease
- Adenocarcinoma
- Adenoma
- Ataxia telangiectasia
- Biliary Tract Neoplasms
- Brain Neoplasms
- Breast cancer
- Breast Diseases
- Breast Neoplasms
- Carcinoma, Non-Small-Cell Lung
- Colorectal Neoplasms
- Esophageal Neoplasms
- Genetic Predisposition to Disease
- Glioma
- Kidney Failure, Chronic
- Laryngeal Neoplasms
- Leukemia, Myeloid, Chronic-Phase
- Lung Neoplasms
- Lymphoma, Follicular
- Lymphoma, Large B-Cell, Diffuse