RAG2 MaxPab rabbit polyclonal antibody (D01)
产品名称： RAG2 MaxPab rabbit polyclonal antibody (D01)
英文名称： RAG2 MaxPab rabbit polyclonal antibody (D01)
产品编号： H00005897-D01
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against a full-length human RAG2 protein.
- Immunogen:
- RAG2 (NP_000527.1, 1 a.a. ~ 527 a.a) full-length human protein.
- Sequence:
- MSLQMVTVSNNIALIQPGFSLMNFDGQVFFFGQKGWPKRSCPTGVFHLDVKHNHVKLKPTIFSKDSCYLPPLRYPATCTFKGSLESEKHQYIIHGGKTPNNEVSDKIYVMSIVCKNNKKVTFRCTEKDLVGDVPEARYGHSINVVYSRGKSMGALFGGRSYMPSTHRTTEKWNSVADCLPCVFLVDFEFGCATSYILPELQDGLSFHVSIAKNDTIYILGGHSLANNIRPANLYRIRVDLPLGSPAVNCTVLPGGISVSSAILTQTNNDEFVIVGGYQLENQKRMICNIISLEDNKIEIREMETPDWTPDIKHSKIWFGSNTGNGTVFLGIPGDNKQVVSEGFYFYMLKCAEDDTNEEQTTFTNSQTSTEDPGDSTPFEDSEEFCFSAEANSFDGDDEFDTYNEDDEEDESETGYWITCCPTCDVDINTWVPFYSTELNKPAMIYCSHGDGHWVHAQCMDLAERTLIHLSAGSNKYYCNEHVEIARALHTPQRVLPLKKPPMKSLRKKGSGKILTPAKKSFLRRLFD
- Host:
- Rabbit
- Reactivity:
- Human, Rat
- Storage Buffer:
- No additive
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody reactive against mammalian transfected lysate.
- MSDS:
Download
- Applications
- Western Blot (Tissue lysate)
- RAG2 MaxPab rabbit polyclonal antibody. Western Blot analysis of RAG2 expression in rat liver.
- Protocol Download
- Western Blot (Transfected lysate)
- Western Blot analysis of RAG2 expression in transfected 293T cell line (H00005897-T02) by RAG2 MaxPab polyclonal antibody.
Lane 1: RAG2 transfected lysate(59.20 KDa).
Lane 2: Non-transfected lysate. - Protocol Download
- Immunoprecipitation
- Immunoprecipitation of RAG2 transfected lysate using anti-RAG2 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with RAG2 purified MaxPab mouse polyclonal antibody (B01P) (H00005897-B01P).
- Protocol Download
- Entrez GeneID:
- 5897
- GeneBank Accession#:
- NM_000536.1
- Protein Accession#:
- NP_000527.1
- Gene Name:
- RAG2
- Gene Alias:
- RAG-2
- Gene Description:
- recombination activating gene 2
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms. [provided by RefSeq
- Other Designations:
- V(D)J recombination-activating protein 2
- Gene Pathway
- Related Disease
- Genetic Predisposition to Disease
- Hematologic Diseases
- Hodgkin Disease
- Immunologic Deficiency Syndromes
- Lymphoma, Non-Hodgkin
- Lymphopenia
- Lymphoproliferative Disorders
- Multiple Myeloma
- Occupational Diseases
- Severe Combined Immunodeficiency
- Severe combined immunodeficiency
- Waldenstrom Macroglobulinemia
- Werner syndrome