FITC标记的热休克蛋白相关蛋白4抗体
产品名称： FITC标记的热休克蛋白相关蛋白4抗体
英文名称： Anti-DNAJA1/FITC
产品编号： HZ-11277R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-DNAJA1/FITC Conjugated antibody
FITC标记的热休克蛋白相关蛋白4抗体
| 产品编号 | bs-11277R-FITC |
| 英文名称 | Anti-DNAJA1/FITC |
| 中文名称 | FITC标记的热休克蛋白相关蛋白4抗体 |
| 别 名 | DJ 2; DJ2; DjA1; DnaJ (Hsp40) homolog, subfamily A, member 1; DnaJ homolog subfamily A member 1; DnaJ protein homolog 2; DNAJ2; Dnaja1; DNJA1_HUMAN; hDJ 2; HDJ-2; HDJ2; Heat shock 40 kDa protein 4; HSP 40-4; heat shock protein DNAJ like 2; Heat shock protein J2; HSDJ; HSJ-2; HSJ2; HSPF4; Human DnaJ protein 2; NEDD7; Neural precursor cell expressed developmentally down regulated 7; OTTHUMP00000021193. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 发育生物学 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 45kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HSP 40-4 (21-110aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: DnaJ-like proteins interact with HSP 70 molecular chaperones and function to facilitate protein folding and mitochondrial protein import. HSP 40-4, also known as HDJ2, is the human DnaJ homolog that functions as a co-chaperone with a cysteine-rich zinc finger domain. The cellular redox enzyme thioredoxin interacts with HSP 40-4, and oxidation and reduction reversibly regulate HSP 40-4 function in response to the changing redox states of the cell. The zinc finger domain of HSP 40-4 may act as a redox sensor of chaperone-mediated protein-folding machinery, since HSP 40-4 inactivation leads to the oxidation of cysteine thiols and a simultaneous release of coordinated zinc. Loss of the HSP 40-4 protein may be linked to severe defects in spermatogenesis that involve aberrant androgen signaling. Function: Co-chaperone of Hsc70. Seems to play a role in protein import into mitochondria. Subcellular Location: Membrane. Similarity: Contains 1 CR-type zinc finger. Contains 1 J domain. Database links: Entrez Gene: 3301 Human Entrez Gene: 15502 Mouse Entrez Gene: 100512008 Pig Entrez Gene: 65028 Rat Omim: 602837 Human SwissProt: P31689 Human SwissProt: P63037 Mouse SwissProt: P63036 Rat Unigene: 445203 Human Unigene: 27897 Mouse Unigene: 64562 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
DNaJ样蛋白与HSP 70分子伴侣相互作用，促进蛋白质折叠和线粒体蛋白导入。HSP40-4，也称为HDJ2，是人类DNJ同源物，其功能是作为富含半胱氨酸的锌指结构域的共伴侣。细胞氧化还原酶硫氧还蛋白与HSP40-4相互作用，氧化还原反应可逆调节HSP40-4的功能，以响应于细胞氧化还原状态的改变。HSP40-4的锌指结构域可作为伴侣蛋白介导的蛋白质折叠机制的氧化还原传感器，因为HSP40-4失活导致半胱氨酸巯基的氧化和同时释放的协调锌。HSP40-4蛋白的丢失可能与精子发生的严重缺陷有关，该异常涉及雄激素信号异常。