ACVRL1 (N-term) Peptide
产品名称: ACVRL1 (N-term) Peptide
英文名称: ACVRL1 (N-term) Peptide
产品编号: P2811
产品价格: 0
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围: null
亚诺法生技股份有限公司(Abnova)
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of ACVRL1.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human ACVRL1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Flow cytometry (1:10-50)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- LC-MS/MS analysis of apical and basolateral plasma membranes of rat renal collecting duct cells.
Yu MJ, Pisitkun T, Wang G, Shen RF, Knepper MA.Mol Cell Proteomics. 2006 Nov;5(11):2131-45. Epub 2006 Aug 9.
- Applications
- Western Blot (Tissue lysate)
- Western blot analysis of ACVRL1 polyclonal antibody (Cat # PAB3475) in mouse heart tissue lysate.
- Western Blot (Transfected lysate)
- Western blot analysis of ACVRL1 polyclonal antibody (Cat # PAB3475) in human chondrocytes (C-28/I2 cells), transfected with empty vector (lane 1, 3) or ACVRL1 (lane 2, 4). RIPA lysis buffer, 20 ug/lane of protein, primary antibody dilution 1 : 1000, blocking solution is 5% milk in TBST (lane 1 and 2), 5% BSA in TBST (lane 3 and 4). Data courtesy of Kenneth Finnson, Montreal General Hospital.
- Western Blot (Transfected lysate)
- Western blot analysis of ACVRL1 (arrow) using rabbit ACVRL1 polyclonal antibody (Cat # PAB3475). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ACVRL1 gene (Lane 2) (Origene Technologies).
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with ACVRL1 polyclonal antibody (Cat # PAB3475) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma.
- Entrez GeneID:
- 94
- Protein Accession#:
- P37023
- Gene Name:
- ACVRL1
- Gene Alias:
- ACVRLK1,ALK-1,ALK1,HHT,HHT2,ORW2,SKR3,TSR-I
- Gene Description:
- activin A receptor type II-like 1
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq
- Other Designations:
- TGF-B superfamily receptor type I,activin A receptor, type II-like kinase 1,serine/threonine-protein kinase receptor R3
- Related Disease
- Anemia, Sickle Cell
- Anemia, sickle cell
- Arteriovenous Malformations
- Asthma
- Asthma
- Cardiovascular Diseases
- Central Nervous System Vascular Malformations
- Chromosome Aberrations
- Diabetes Mellitus, Type 2
- Edema
- Epistaxis
- Genetic Predisposition to Disease
- Heart Diseases
- Hyperparathyroidism, Secondary
- Hyperplasia
- Hypertension, Pulmonary
- Intracranial Aneurysm
- Intracranial Arteriovenous Malformations
- Liver Cirrhosis