重组人可溶性CD14(Human sCD14,Human soluble CD14)

Wnt-3a belongs to the Wnt family of signaling proteins that play a key role in maintaining the integrity of embryonic and adult tissues. Expression of Wnt-3a occurs primarily along the dorsal midline across overlapping regions of the Central Nervous System (CNS). Wnt-3a signaling is essential for various morphogenetic events including embryonic patterning, cell determination, cell proliferation, CNS development, and cytoskeletal formation. Like other members of this family, Wnt-3a contains a highly conserved lipid modified cysteine rich domain that is essential for cell signaling. During a biochemical process called the canonical Wnt pathway; Wnt family members bind to and activate seven-pass transmembrane receptors of the Frizzled family ultimately leading to the disruption of β-Catenein degradation. Intracellular accumulation of β-Catenin increases translocation of the protein into the nucleus where it binds to TCF/LEF transcription factors to promote gene expression. Lack of Wnt signaling disrupts transcriptional activation of tumor suppressor genes and has shown to result in neoplastic transformation, oncogenesis, and human degenerative diseases. Recombinant murine Wnt-3a is a monomeric glycoprotein containing 334 amino acid residues. Due to glycosylation, the murine Wnt-3a migrates at an apparent molecular weight of approximately 38.0-41.0 kDa by SDS-PAGE analysis under non-reducing conditions. 

重组人可溶性CD14(Human sCD14,Human soluble CD14)

IL－2是一种淋巴因子，可提高人体对病毒、细菌、真菌、原虫等感染的免疫应答，使细胞毒性T细胞、 自然杀伤细胞和淋巴因子激活的杀伤细胞(LAK)增殖，并升高其余伤活性，进而清除体内肿瘤细胞和病毒感染细胞等，还可促进干扰素、 肿瘤坏死因子等细胞因子的分泌和抗体产生。它是机体免疫应答的核心物质，是一种免疫增强剂，具有抗病毒、抗肿瘤和增强机体免疫功能等作用。最新研究证实：IL－2与内源性脑啡肽具有共同的抗原决定簇和相似的空间结构部份，故它能竞争结合到 中枢神经系统中的阿片受体上，提高病阈，产生中枢及外周神经镇痛作用。它还可以在中枢神经系统通过某种由阿片受体介导的通路对 交感神经系统的兴奋施加抑制性影响。

重组人可溶性CD14(Human sCD14,Human soluble CD14)