ACE2 polyclonal antibody
产品名称： ACE2 polyclonal antibody
英文名称： ACE2 polyclonal antibody
产品编号： PAB4686
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of ACE2.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human ACE2.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:50-200)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- The novel angiotensin-converting enzyme (ACE) homolog, ACE2, is selectively expressed by adult Leydig cells of the testis.
Douglas GC, O'Bryan MK, Hedger MP, Lee DK, Yarski MA, Smith AI, Lew RA.Endocrinology. 2004 Oct;145(10):4703-11. Epub 2004 Jul 1.
- 2.
- ACE2: from vasopeptidase to SARS virus receptor.
Turner AJ, Hiscox JA, Hooper NM.Trends Pharmacol Sci. 2004 Jun;25(6):291-4.
- 3.
- ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis.
Towler P, Staker B, Prasad SG, Menon S, Tang J, Parsons T, Ryan D, Fisher M, Williams D, Dales NA, Patane MA, Pantoliano MW.J Biol Chem. 2004 Apr 23;279(17):17996-8007. Epub 2004 Jan 30.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of ACE2 polyclonal antibody (Cat # PAB4686) in HL-60 cell lysate (35 ug/lane). ACE2 (SARS-R) (arrow) was detected using the purified polyclonal antibody.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with ACE2 polyclonal antibody (Cat # PAB4686) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma.
- Entrez GeneID:
- 59272
- Protein Accession#:
- NP_068576;Q9BYF1
- Gene Name:
- ACE2
- Gene Alias:
- ACEH,DKFZp434A014
- Gene Description:
- angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
- Omim ID:
- 300335
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq
- Other Designations:
- ACE-related carboxypeptidase,OTTHUMP00000022963,angiotensin I converting enzyme 2,angiotensin converting enzyme-like protein
- Gene Pathway
- Related Disease
- Arrhythmias, Cardiac
- Atrial Fibrillation
- Cardiomyopathy, Hypertrophic
- Cardiovascular Diseases
- Coronary Disease
- Death, Sudden, Cardiac
- Diabetes Mellitus, Type 1
- Diabetes Mellitus, Type 2
- Diabetic Nephropathies
- Disease Progression
- Edema
- Genetic Predisposition to Disease
- Hypertension
- Hypertrophy, Left Ventricular
- Hypotension, Orthostatic
- Intracranial Aneurysm
- Malaria, Cerebral
- Metabolic Syndrome X
- Sarcoidosis, Pulmonary