MYC polyclonal antibody
产品名称： MYC polyclonal antibody
英文名称： MYC polyclonal antibody
产品编号： PAB18101
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of MYC.
- Immunogen:
- A synthetic peptide corresponding to human MYC.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- This antibody is specific to MYC.
- Form:
- Liquid
- Purification:
- Affinity purification
- Concentration:
- 1 mg/mL
- Storage Buffer:
- In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
Immunofluorescence (1:500-1:1000)
ELISA (1:40000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation.
Welcker M, Orian A, Jin J, Grim JE, Harper JW, Eisenman RN, Clurman BE.Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):9085-90. Epub 2004 May 18.
- 2.
- Phosphorylation by glycogen synthase kinase-3 controls c-myc proteolysis and subnuclear localization.
Gregory MA, Qi Y, Hann SR.J Biol Chem. 2003 Dec 19;278(51):51606-12. Epub 2003 Oct 16.
- 3.
- The c-Myc transactivation domain is a direct modulator of apoptotic versus proliferative signals.
Chang DW, Claassen GF, Hann SR, Cole MD.Mol Cell Biol. 2000 Jun;20(12):4309-19.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of extracts from HeLa cells treated with Forskolin (40 nM, 30 min), using MYC polyclonal antibody (Cat # PAB18101).
Peptide "+" means "peptide blocking".
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using MYC polyclonal antibody (Cat # PAB18101).
Peptide "+" means "peptide blocking".
- Entrez GeneID:
- 4609
- Protein Accession#:
- P01106
- Gene Name:
- MYC
- Gene Alias:
- bHLHe39,c-Myc
- Gene Description:
- v-myc myelocytomatosis viral oncogene homolog (avian)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq
- Other Designations:
- avian myelocytomatosis viral oncogene homolog,myc proto-oncogene protein,v-myc avian myelocytomatosis viral oncogene homolog
- Related Disease
- Alzheimer Disease
- Alzheimer disease
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- Breast Neoplasms
- Carcinoma, Non-Small-Cell Lung
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- Cardiovascular Diseases
- Chromosome Aberrations
- Colorectal Neoplasms
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- Disease Progression
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- Hematologic Diseases
- Hodgkin Disease
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- Lymphoma, B-Cell
- Lymphoma, B-Cell, Marginal Zone