G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPRC5C (G protein-coupled receptor, family C, group 5, member C), also known as RAIG3, is a 441 amino acid multi-pass membrane protein that localizes to cytoplasmic vesicles and belongs to the G protein-coupled receptor family. Expressed at high levels in stomach, liver, prostate, kidney and pancreas, GPRC5C is thought to function as a retinoic acid-inducible GPR that may play a role in signaling events throughout the cell. GPRC5C is subject to DNA damage-dependent phosphorylation, probably by ATM or ATR.