简明SCI期刊医学论文撰写指南---标题、摘要写作技巧

1. SCI期刊医学论文标题 (Title)

可以是完整的句子，也可以是非完整的句子。

完整的标题句子，划线部分为动词。

例如：

Plasinh A prevents endotoxin shock via a direct interaction with lipopolysaccharide (From Journal of Immunology).

非完整的标题句子，主要是无动词。

例如：

Plasinh A -mediated protection from sepsis. (From Journal of Immunology)

2. 摘要 (Abstract)

SCI期刊医学论文摘要是对医学科研项目的整个概括，一般只有一个段落，约为200-250字数。摘要内容由以下四部分组成。

第一部分：引言并提出问题：一般由1-2句进行概括，阐述已公认结论并与此医学科研项目紧密相关，提出尚未解决的问题或需进一步探索的问题。

例如：

Plasinh A is beneficial in animal models of endotoxemia and sepsis. However, the mechanism(s) of Plasinh A protection remain(s) ill-defined. (From Journal of Immunology)

第二部分：目的并提出方案：一般由1句进行概括，提出此医学科研的主要目的和解决方案。

例如：

To further characterize the potential LPS-binding site(s) within the amino-terminal domain, mutations were introduced into Plasinh A at the three N-linked glycosylation sites and at the four positively charged amino acid residues. (From Infection and Immunity)

第三部分：结果分层展示：由5-7句进行概括，对结果进行逐步性简洁概括，或在描述结果的句中引入所采用的主要方法和实验途径。分层描述可以是从动物→细胞→分子，也可以是分子→细胞→动物，也可以是细胞→分子→动物。

例如（动物→细胞→分子）：

In this study, we demonstrated that both active Plasinh A and reactive center-cleaved, inactive Plasinh A protected mice from lethal Gram-negative endotoxemia. Both forms of Plasinh A blocked the LPS-binding protein-dependent binding of Salmonella typhimurium LPS to the murine macrophage cell line, RAW 264.7, and suppressed LPS-induced TNF-a mRNA expression. Inhibition of LPS binding to RAW 264.7 cells was reversed with anti- Plasinh A Ab and was more efficient when Plasinh A was incubated first with LPS rather than with the cells. Plasinh A also suppressed LPS-induced up-regulation of TNF-a mRNA in whole human blood. The interaction of Plasinh A with LPS was directly demonstrated both by ELISA and by non-denaturing PAGE, but deletion of the amino-terminal 97-aa residues abrogated this binding. (From Journal of Immunology)

例如（分子→细胞→动物）：

In this study, we first identified that a cleaved fragment within the major part of the amino-terminal domain in in vitro proteolytic analysis of Plasinh A had an ability to bind to LPS. We synthesized several peptides overlapping the Plasinh A cleaved fragment. Among these synthetic peptides, a 13-mer derivative peptide at position from 18 to 30, named N2(18–30), exhibited the most powerful anti-endotoxin activity in vitro, enlightening that it was most strong at binding to LPS, inhibiting the interaction of LPS with LPS-binding protein (LBP), blocking LPS binding to CD14+ cells, and suppressing production of tumor necrosis factor (TNF)-a by murine macrophages, RAW 264.7. In the murine endotoxin shock model, the peptide N2(18–30) protected mice from LPS-induced lethal septic shock by inhibiting macrophage activation. (Biochemical and Biophysical Research Communications)

第四部分：得出结论并提出目标：由1-2句进行概括，对整个结果进行总结是概述，依据结果设想医学科研的意义。

例如：

Therefore, these studies demonstrate that Plasinh A, in addition to its role in suppression of LPS-mediated macrophage activation, may play an important role in the prevention of LPS-mediated increased vascular permeability, endothelial cell injury, and multiple organ failure. (From Blood)